Mission Hills is an urban residential community of the San Fernando Valley, within the City of Los Angeles, California.
It is near the northern junction of the Golden State Freeway (I-5) and the San Diego Freeway (I-405). The Ronald Reagan Freeway (Cal 118) halves the community. Mission Hills is at the northern end of the long Sepulveda Boulevard. Other main thoroughfares are San Fernando Mission Boulevard, Woodman Avenue, and Rinaldi, Brand, Chatsworth, Devonshire, and Lassen Streets. The boundaries are roughly Sepulveda Blvd and Interstate 405 to the west, Interstate 5 to the north and east, Van Nuys Boulevard to the southeast, and Lassen Street to the south. The Granada Hills community lies to the west, Sylmar to the north, the city of San Fernando to the northeast, Pacoima to the east, Arleta to the southeast, and Panorama City to the south.
The community is noteworthy for the stately Spanish Mission San Fernando Rey de España (1784). The Andrés Pico Adobe, the second oldest residence still standing in Los Angeles, is also here. People are still buried in the San Fernando Mission Cemetery.